www.alzheimers.org.uk This film looks at what happens to a brain with Alzheimer’s disease, including the development of amyloid plaques and tau tangles. Alzheimer’s disease is the most common form of dementia. To download a transcript of the film, please click here http Please watch our other videos to see how brain cells function, hear what dementia is, and to hear more about Alzheimer’s disease, Posterior Cortical Atrophy, vascular dementia, dementia with Lewy bodies, fronto-temporal dementia and other rarer causes of dementia. Alzheimer’s Society is dedicated to defeating dementia through research. Our unique research programme funds research into the cause, cure, care and prevention of dementia to improve treatment for people today and to search for a cure for tomorrow. We are the only organisation to work with leading scientists and people affected by dementia to ensure our research influences practice and transforms lives. With the right investment, dementia can be defeated. www.alzheimers.org.uk If you have found this tool useful please consider donating to our research programme by following this link www.alzheimers.org.ukThere are more than 750000 people in the UK affected by dementia with numbers set to rise to 1 million by 2021. More than half of these have Alzheimer’s disease. Alzheimer’s Society is the UK’s leading care and research charity for people with dementia and those who care for them. Support the fight against dementia www.alzheimers.org.uk
Air date: Wednesday, December 07, 2011, 3:00:00 PM Timedisplayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: O-GlcNAcylation, the cycling of a N-acetylglucosamine monosaccharide on Ser(Thr) residues of nuclear and cytoplasmic proteins, serves as a nutrient/stress sensor to regulate signaling, transcription and cellular metabolism. Recent phospho- and glycomic approaches have shown that an increase in global O-GlcNAcylation affects phospho-site occupancy at nearly every actively cycling site. A chemico-enzymatic photochemical enrichment method, combined with ETD-mass spectrometry allows detection of O-GlcNAc site occupancy at a level of sensitivity comparable to that possible for phosphorylation. These analyses show that crosstalk between site-specific phosphorylation and O-GlcNAcylation is extensive. Many kinases are both modified and regulated by O-GlcNAcylation. The major sensor of cellular energy state, AMPK is O-GlcNAcylated. AMPK and O-GlcNAc transferase share many substrates and the two systems directly interact. Major signaling cascades (eg. CDK1, aurora kinase, polo kinase) that regulate cell division are strikingly affected by a small change in O-GlcNAcylation. O-GlcNAc is part of the histone code, but many of the O-GlcNAc residues are at sites interacting with DNA in the nucleosome, not in the histone tails. Multiple core ribosome proteins are modified by O-GlcNAc, which plays a role in ribosome biogenesis and …
Malnourishment causes cognitive decline, dementia and Alzheimer’s disease. Andreas Moritz explains the factors that cause and contribute to Alzheimer’s Disease. Too little insulin causes Alzheimer’s to develop, which means diabetics are more at risk for developing the disease. Raena Morgan: There are many repercussions health wise to having diabetes, but is there a link to Alzheimer’s? Andreas Moritz: There is. Actually, Alzheimer’s is a progressive destruction of the cells in the brain, in certain parts of the brain. And you basically have dementia when the mind can no longer correlate to the environment or have access to certain information that you once had stored as memory. RM: Cognitive decline. AM: So that basically means that the brain and nervous system is suffering from severe malnourishment and you will have similar experiences- RM: Malnourishment? AM: -in people that are malnourished. That means you go to countries where people are not getting enough food, they develop all kinds of dementia symptoms. RM: They do. AM: So it is not really a separate illness that we call that; it is progressive malnourishment, and that can be caused by a number of factors. Typically, constipation, chronic constipation, that many of the Alzheimer’s patients, they don’t go to the toilet. They are holding on to their own fecal matter, the waste products are starting to back up. It’s like a river that runs in one direction. You put a dam in front of it, it’s backing up, it flows …
An 87 year-old Texas woman bravely faced Alzheimer’s disease by her husband’s side. She now runs a support group sharing her wisdom and coping strategies with other families.
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The O’Neill Foundation for Community Health has produced a series of videos on a variety of timely medical issues designed primarily for use in faith communities. Each video features an interview with a medical expert from the Johns Hopkins Medical Institutions. This one is Alzheimer’s Disease with Peter V. Rabins, MD, MPH
geriatricresearch.medicine.dal.ca A short film explaining new insights into repetitive talk in Alzheimer’s disease patients. From the Geriatric Medicine Research Unit, in Halifax, Nova Scotia, Canada.
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